1985. Refinement and reduction goals should be balanced on a case-by-case basis. ILAR J 40:1-37. Scientific review committees and journal editors may choose to refer to multiple sections of the Guide to determine whether scientists contributing proposals and manuscripts have met the appropriate standards in their planned use of animals. Gonder JC, Smeby RR, Wolfle TL. Washington: National Academy Press. Bioterrorism Agents: Appropriate Use of Animal Models (2006) Guidelines for the Humane Transportation of Research Animals (2006) Science, Medicine, and Animals: Teacher’s Guide (2005) Jump up to the previous page or down to the next one. These principles direct the research community to accept responsibility for the care and use of animals during all phases of the research effort. } Show this book's table of contents, where you can jump to any chapter by name. Marilyn J. November 2007. (Adapted from the U.S. Government Principles for the Utilization and Care of Vertebrate Animals Used in Testing, Research, and Training.) 1959. It includes the establishment and support of an IACUC or equivalent ethical oversight committee and the maintenance of an environment in which the IACUC can function successfully to carry out its responsibilities under the Guide and applicable laws and policies. Sign up for email notifications and we'll let you know about new publications in your areas of interest when they're released. Finally, members of the public should feel assured that adherence to the Guide will ensure humane care and use of laboratory animals. It is the policy of Washington University in St. Louis to comply with all federal and state laws and regulations pertainin… 2006. Animal use shall be planned and conducted so as to avoid or minimize pain and distress to the animals. The Committee and its chair are appointed by the Vice Chancellor for Research and Economic Development for 3-year staggered terms, and must have at least five (5) members including a veterinarian, a scientist, a non-scientist and a community representative not otherwise affiliated with the University. Available at http://ecfr.gpoaccess.gov/cgi/t/text/text-idx?sid=8314313bd7adf2c9f1964e2d82a88d92andc=ecfrandtpl=/ecfrbrowse/Title09/9cfrv1_02.tpl; accessed January 14, 2010. Published in the Federal Register, May 20, 1985, vo. { Studies that may result in severe or chronic pain or significant alterations in the animals’ ability to maintain normal physiology, or adequately respond to stressors, should include descriptions of appropriate humane endpoints or provide science-based justification for not using a particular, commonly accepted humane endpoint. Greenbelt MD: Scientists Center for Animal Welfare. Employees working with animals in a research environment may be exposed to a variety of occupational Protective clothing should be changed as appropriate to minimize cross contamination between species or activities in different animal rooms within the facility. Animal testing, also known as animal experimentation, animal research and in vivo testing, is the use of non-human animals in experiments that seek to control the variables that affect the behavior or biological system under study. The animal care and use program (the Program) means the policies, procedures, standards, organizational structure, staffing, facilities, and practices put into place by an institution to achieve the humane care and use of animals in the laboratory and throughout the institution. Compliance with these laws, regulations, policies, and standards (or subsequent revised versions) in the establishment and implementation of a program of animal care and use is discussed in Chapter 2. Rodent Handling and Restraint Techniques. The IACUC assures that animal care and use are in compliance with all federal, state and local regulations as well as University policy and assurances. Ethical considerations discussed here and in other sections of the Guide should serve as a starting point; readers are encouraged to go beyond these provisions. Entirety, as there are many concepts throughout that may be helpful, of... Recommendations in the Guide go back to the next one Reports from the Academies online for free with! Set out below are important for a wide and diverse audience, including to... Applicable legal or policy Requirements, the higher standard should apply can in... All phases of the Guide with additional assistance in implementing their responsibilities be contrasted with field studies which... Different from applicable legal or policy may not be eliminated based on the goals of public. And animal Welfare: Definition, application and assessment, Parts I and II to! 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